Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats.

  title={Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats.},
  author={Bernadene A. Magnuson and Jeremy Appleton and Gregory B. Ames},
  journal={Journal of agricultural and food chemistry},
  volume={55 3},
Methylsulfonylmethane (MSM) is a sulfur-containing compound found in a wide range of human foods including fruits, vegetables, grains, and beverages. More recently, it has been marketed as a dietary supplement worldwide. The objective of this study was to evaluate the pharmacokinetic profile and distribution of radiolabeled MSM in rats. Male Sprague-Dawley rats were administered a single oral dose of [35S]MSM (500 mg/kg), and blood levels of radioactivity were determined at different time… CONTINUE READING


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