Pharmacokinetics and disposition of the lipid‐lowering drug acifran in normal subjects and in patients with renal failure

@article{Cayen1990PharmacokineticsAD,
  title={Pharmacokinetics and disposition of the lipid‐lowering drug acifran in normal subjects and in patients with renal failure},
  author={Mitchell N. Cayen and Eckhardt S. Ferdinandi and David R. Hicks and Raquel Gonz{\'a}lez and L Cosyns and J. F. Dubuc and M. Kraml and Kathleen D. Edwards},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1990},
  volume={47}
}
The pharmacokinetics and metabolic fate of the antihyperlipidemic drug acifran were assessed after a single oral dose of the 14C‐labeled drug to healthy male volunteers. Peak serum acifran and radioactivity concentrations were attained 1 to 2 hours after dosing, and the drug was eliminated with a half‐life of 1.6 hours. Virtually all of the recovered dose was excreted in the urine. All of the serum and urinary radioactivity was caused by unconjugated acifran. In patients with moderate chronic… 
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    British journal of pharmacology
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NMR Studies of Drugs. Applications of Achiral and Chiral Lanthanide Shift Reagents to Acifran Methyl Ester. LSR Binding to a Multifunctional Substrate.
Abstract The antihyperlipoproteinemic agent, acifran, has been studied as its racemic methyl ester, 1, by 60 MHz 1H NMR in CDC13 solution at 28±1° with the added achiral lanthanide shift reagent

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TLDR
The disposition of acifran was similar in rats and dogs; the drug was rapidly absorbed and eliminated, and underwent no detectable biotransformation, and there was no tissue retention and excretion was mainly in the urine.
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