Pharmacokinetics and clinical toxicity of quinine overdosage: lack of efficacy of techniques intended to enhance elimination.

@article{Bateman1985PharmacokineticsAC,
  title={Pharmacokinetics and clinical toxicity of quinine overdosage: lack of efficacy of techniques intended to enhance elimination.},
  author={D Nicolas Bateman and Peter Blain and Ken W. Woodhouse and Michael D Rawlins and Heather Dyson and R Heyworth and Laurie F Prescott and Alex T Proudfoot},
  journal={The Quarterly journal of medicine},
  year={1985},
  volume={54 214},
  pages={125-31}
}
We report clinical details in 16 cases of quinine poisoning. Plasma quinine concentrations above 15 mg/l were associated with increased risks of permanent visual damage and of cardiac arrhythmias from which one of our patients died. The rate of quinine elimination was not significantly altered by forced acid diuresis in five patients (t 1/2 25.1 +/- SEM 4.6 h) as compared to eight patients treated conservatively (t 1/2 26.5 +/- SEM 5.78 h). Neither urinary pH or flow rate correlated… CONTINUE READING
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