Pharmacokinetics and clinical effectiveness of methylphenidate.

  title={Pharmacokinetics and clinical effectiveness of methylphenidate.},
  author={Hui C. Kimko and J Thomas Cross and Darrell R. Abernethy},
  journal={Clinical pharmacokinetics},
  volume={37 6},
Methylphenidate is prescribed for over 90% of children in the US diagnosed as having attention-deficit hyperactivity disorder (ADHD). Although ADHD has been widely studied, the use of methylphenidate in ADHD still poses a number of unresolved questions, including its pharmacodynamic characteristics (drug concentration-effect relationship) and the effect of long term treatment on the patient's psychopathology later in life. The objective of this review is to provide an analysis of the… CONTINUE READING
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