Pharmacokinetics and biodistribution of polymeric micelles of paclitaxel with Pluronic P123

@article{Han2006PharmacokineticsAB,
  title={Pharmacokinetics and biodistribution of polymeric micelles of paclitaxel with Pluronic P123},
  author={Li-mei Han and Jie Guo and Li-jun Zhang and Qing-song Wang and Xiao-ling Fang},
  journal={Acta Pharmacologica Sinica},
  year={2006},
  volume={27},
  pages={747-753}
}
AbstractAim:To investigate the preparation, in vitro release, in vivo pharmacokinetics and tissue distribution of a novel polymeric micellar formulation of paclitaxel (PTX) with Pluronic P123.Methods:The polymeric micelles of paclitaxel with Pluronic P123 were prepared by a solid dispersion method. The characteristics of micelles including particle size distribution, morphology and in vitro release of PTX from micelles were carried out. PTX-loaded micellar solutions were administered through… CONTINUE READING
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