• Corpus ID: 70384952

Pharmacokinetics and biodistribution of paclitaxel following intrauterine administration of PACLIMER® microspheres in female New Zealand rabbits

@article{Dordunoo2006PharmacokineticsAB,
  title={Pharmacokinetics and biodistribution of paclitaxel following intrauterine administration of PACLIMER{\textregistered} microspheres in female New Zealand rabbits},
  author={Stephen K. Dordunoo and William C. Vincek and Harris Howland and George Liu and Nobel Nemieboka and Kenneth S. Bauer},
  journal={Cancer Research},
  year={2006},
  volume={66},
  pages={730-731}
}
Proc Amer Assoc Cancer Res, Volume 47, 2006 3103 Introduction: The efficacy of high-dose chemotherapy in a subset of malignancies suggests that resistance may not be absolute and laboratory studies that show that sufficiently higher doses of most antineoplastic agents overcome all mechanisms of resistance. However, higher doses in patients are associated with unacceptable toxicity which may be circumvented by targeting the drug to the diseased tissues. We have investigated the…