Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation.

@article{Gershkovich2009PharmacokineticsAB,
  title={Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation.},
  author={P. Gershkovich and E. Wasan and Molly Lin and O. Sivak and C. Leon and J. G. Clement and K. Wasan},
  journal={The Journal of antimicrobial chemotherapy},
  year={2009},
  volume={64 1},
  pages={
          101-8
        }
}
OBJECTIVES To assess the pharmacokinetics and biodistribution of amphotericin B (AmB) following oral administration in a novel mono/diglyceride-phospholipid formulation and to compare with intravenous (iv) administrations using commercial formulations. METHODS Rats were allocated into the following treatment groups: oral gavage of AmB dispersed in mono/diglyceride-phospholipid formulation at doses of 4.5 and 10 mg/kg; iv bolus administration of 0.8 mg/kg Fungizone; iv bolus of 5 mg/kg Abelcet… Expand
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