Pharmacokinetics and bioavailability of three dyphylline preparations

  title={Pharmacokinetics and bioavailability of three dyphylline preparations},
  author={J. J. Stablein and Samie Samaan and Samuel C. Bukantz and Richard Funk Lockey},
  journal={European Journal of Clinical Pharmacology},
The pharmacokinetics and bioavailability of 3 oral dyphylline preparations, solution (S), regular (R) and sustained release (SR), were studied in 8 healthy subjects (mean age 25 years). A single dose of each preparation, 20 mg·kg−1, was given at one week intervals and multiple serum samples obtained over 24 h. Drug levels were measured by high performance liquid chromatography. No adverse effects were found. The dyphylline half-life for the solution was 2.16±0.18 h and for the tablet 2.59±0.56… CONTINUE READING