Pharmacokinetics and bioavailability of intravenous and oral chlordesmethyldiazepam in humans

@article{Bareggi2004PharmacokineticsAB,
  title={Pharmacokinetics and bioavailability of intravenous and oral chlordesmethyldiazepam in humans},
  author={S. Bareggi and G. Truci and S. Leva and L. Zecca and R. Pirola and S. Smirne},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={34},
  pages={109-112}
}
  • S. Bareggi, G. Truci, +3 authors S. Smirne
  • Published 2004
  • Medicine
  • European Journal of Clinical Pharmacology
  • SummarySix healthy, fasting volunteers were given single doses of chlordesmethyldiazepam by 1 mg i. v., or as drops or tablets. Chlordesmethyldiazepam and its metabolite, lorazepam, in multiple plasma samples and in urine collected for 120 h after each dose were determined by electron-capture GLC.Mean kinetic variables for intravenous chlordesmethyldiazepam were: volume of distribution, 1.71 l · kg−1; elimination half-life, 113 h; total clearance, 0.21 ml · min−1 · kg−1; cumulative excretion of… CONTINUE READING
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