Pharmacokinetics and bioavailability of mycophenolic acid after intravenous administration and oral administration of mycophenolate mofetil to heart transplant recipients.

@article{Armstrong2005PharmacokineticsAB,
  title={Pharmacokinetics and bioavailability of mycophenolic acid after intravenous administration and oral administration of mycophenolate mofetil to heart transplant recipients.},
  author={Victor William Armstrong and Gero Tenderich and Maria Shipkova and Amin Parsa and Reiner Koerfer and Heike Schroeder and Michael Oellerich},
  journal={Therapeutic drug monitoring},
  year={2005},
  volume={27 3},
  pages={315-21}
}
The aim of this prospective study was to characterize the multiple-dose pharmacokinetics of mycophenolic acid (MPA) after administration of a 3-hour intravenous (IV) infusion of mycophenolate mofetil (MMF, CellCept) at a dose level of 1.5 g every 12 hours for 5 full days to cardiac allograft recipients and to compare the bioavailability of MPA after a switch from the IV infusion to an oral dose of 1.5 g every 12 hours from day 6. In addition to MMF, patients received cyclosporine and… CONTINUE READING