Pharmacokinetics and bioavailability of a metformin/glyburide tablet administered alone and with food.

@article{Marathe2000PharmacokineticsAB,
  title={Pharmacokinetics and bioavailability of a metformin/glyburide tablet administered alone and with food.},
  author={Punit H. Marathe and Michelle E. Arnold and Jeff B Meeker and Douglas S. Greene and Rashmi H. Barbhaiya},
  journal={Journal of clinical pharmacology},
  year={2000},
  volume={40 12 Pt 2},
  pages={
          1494-502
        }
}
Two randomized crossover studies were conducted to evaluate the pharmacokinetics (including food effect) of fixed-combination metformin/glyburide tablets. Pharmacokinetics and bioavailability of two strengths (500 mg/2.5 mg and 500 mg/5 mg) of metformin/glyburide tablets were assessed relative to coadministered metformin and glyburide tablets in study 1. The effect of a high-fat meal on the bioavailability of a metformin/glyburide (500 mg/5 mg) tablet was assessed relative to the fasted… CONTINUE READING
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