Pharmacokinetics and bacteriologic efficacy of moxalactam, cefotaxime, cefoperazone, and rocephin in experimental bacterial meningitis.

Abstract

The pharmacokinetics and bacteriologic efficacy of four beta-lactam antibiotics were studied in the serum and cerebrospinal fluid (CSF) of rabbits using two test strains, Escherichia coli type K1 and group B Streptococcus type III, and 24 gram-positive isolates. Although moxalactam, cefotaxime, cefoperazone, and rocephin are active in vitro against gram… (More)

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@article{Schaad1981PharmacokineticsAB, title={Pharmacokinetics and bacteriologic efficacy of moxalactam, cefotaxime, cefoperazone, and rocephin in experimental bacterial meningitis.}, author={Urs Beat Schaad and George H Mccracken and Christine A. Loock and M. L. Thomas}, journal={The Journal of infectious diseases}, year={1981}, volume={143 2}, pages={156-63} }