Pharmacokinetics and analgesic effect of ropivacaine during continuous epidural infusion for postoperative pain relief.

@article{Erichsen1996PharmacokineticsAA,
  title={Pharmacokinetics and analgesic effect of ropivacaine during continuous epidural infusion for postoperative pain relief.},
  author={C J Erichsen and Jan Sj{\"o}vall and Henrik Kehlet and Cecilia Hedlund and Tina Arvidsson},
  journal={Anesthesiology},
  year={1996},
  volume={84 4},
  pages={834-42}
}
BACKGROUND The pharmacokinetics and clinical efficacy of ropivacaine (2.5 mg/ml) during a 24-h continuous epidural infusion for postoperative pain relief in 20 patients scheduled for abdominal hysterectomy were characterized using an open-label, increasing-dose design. METHODS Through an epidural catheter inserted at T10-T12, a test dose of 7.5 mg ropivacaine was given 3 min before a bolus dose of 42.5 mg and immediately followed by a 24-h continuous epidural infusion with either 10 or 20 mg… CONTINUE READING
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