Pharmacokinetics and Safety Profile of Ispronicline (TC‐1734), a New Brain Nicotinic Receptor Partial Agonist, in Young Healthy Male Volunteers

@article{Dunbar2006PharmacokineticsAS,
  title={Pharmacokinetics and Safety Profile of Ispronicline (TC‐1734), a New Brain Nicotinic Receptor Partial Agonist, in Young Healthy Male Volunteers},
  author={Geoffrey C. Dunbar and Agn{\`e}s Demazi{\`e}res and A. M. Jiménez Monreal and Claire Cisterni and D{\'e}borah Metzger and Ramana V Kuchibhatla and R{\'e}my Luthringer},
  journal={The Journal of Clinical Pharmacology},
  year={2006},
  volume={46}
}
Recent research suggests that drugs activating nicotine acetylcholine receptors might be promising therapy in cognitive decline seen in the elderly, including Alzheimer's disease. Ispronicline (TC‐1734), a brain‐selective α4β2 nicotine acetylcholine receptor partial agonist, has shown memory‐enhancing properties in rodents and a good tolerability profile. The safety and the full pharmacokinetic profile of TC‐1734 and its N‐desalkylated metabolite, TC‐1784, were investigated in 2 phase I studies… 

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