Pharmacokinetics and Pulmonary Distribution of Clarithromycin and Rifampicin after Concomitant and Consecutive Administration in Foals.

@article{Berlin2016PharmacokineticsAP,
  title={Pharmacokinetics and Pulmonary Distribution of Clarithromycin and Rifampicin after Concomitant and Consecutive Administration in Foals.},
  author={S Berlin and Lena Spieckermann and Stefan Oswald and Markus Keiser and Stefan Lumpe and Anett Ullrich and Markus Grube and Mahmoud Hasan and Monica Venner and Werner Siegmund},
  journal={Molecular pharmaceutics},
  year={2016},
  volume={13 3},
  pages={1089-99}
}
Drug interactions often result from multiple pharmacokinetic changes, such as after rifampicin (RIF) and clarithromycin (CLA) in the treatment of abscessing lung diseases. Comedication of RIF may interact with CLA disposition by either induction of presystemic elimination processes and/or inhibition of uptake mechanisms because it regulates gene transcription and modulates function of various CYP enzymes, multidrug efflux and uptake transporters for which CLA is a substrate. To distinguish the… CONTINUE READING