Pharmacokinetics and Potency of Progestins used for Hormone Replacement Therapy and Contraception

@article{Stanczyk2004PharmacokineticsAP,
  title={Pharmacokinetics and Potency of Progestins used for Hormone Replacement Therapy and Contraception},
  author={Frank Z. Stanczyk},
  journal={Reviews in Endocrine and Metabolic Disorders},
  year={2004},
  volume={3},
  pages={211-224}
}
  • F. Stanczyk
  • Published 1 September 2002
  • Medicine
  • Reviews in Endocrine and Metabolic Disorders
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References

SHOWING 1-10 OF 53 REFERENCES
Use of the name "Progestin".
TLDR
There is considerable confusion concerning the use of the term "progestin" in referring to progestational compounds and a consensus should be established to determine the generic name of progestations to avoid confusion and ambiguity in definition. Expand
A 1-year pharmacokinetic investigation of a novel oral contraceptive containing drospirenone in healthy female volunteers
TLDR
In conclusion, drospirenone was absorbed at a similar rate as other synthetic progestogens contained in various oral contraceptives, as indicated by similar tmax values. Expand
Drospirenone: pharmacology and pharmacokinetics of a unique progestogen.
TLDR
Based on the biochemical and pharmacodynamic data, drospirenone appears to be a viable alternative to the currently available progestogens. Expand
Improved Bioavailability of a Micronized Megestrol Acetate Tablet Formulation in Humans
TLDR
A significant increase in the drug bioavailability was observed, in either the rate or the extent of absorption, in a micronized megestrol acetate tablet formulation compared to a conventional form. Expand
Effect of low-dose oral contraceptives on androgenic markers and acne.
TLDR
Low-dose OC (EE, 20 micrograms) are effective in reducing circulating androgens and acne lesions without causing weight gain and, although LNG and NETA affected secondary markers differently, both OC formulations produced an equivalent decrease in bioavailable. Expand
Nomenclature of the gonane progestins.
TLDR
The use of gonane nomenclature to classify the levonorgestrel and norethindrone families of progestins, respectively, originates from the systemic name of these compounds. Expand
Determination of medrogestone in plasma by high-performance liquid chromatography.
TLDR
The developed method for plasma sample preparation and the evaluated HPLC condition were further applied to an in vivo pharmacokinetic study and prevented interference with the UV absorbance of medrogestone by endogenous steroids in plasma by reacting plasma with oxalyl chloride. Expand
In vivo conversion of norethisterone and norethisterone acetate to ethinyl etradiol in postmenopausal women.
TLDR
It is concluded that at therapeutic doses of the progestogens, the exposure to metabolically derived ethinyl estradiol is probably of little clinical significance not only in fertile women using oral contraceptive combination preparations containing norethisterone and ethinyl Estradiol, but also in postmenopausal women who receive oral doses of estradio for estrogen replacement. Expand
Plasma concentrations of medroxyprogesterone acetate, estradiol and estrone following oral administration of Klimaxil, Trisequence/Provera and Divina. A randomized, single-blind, triple cross-over bioavailability study in menopausal women.
TLDR
There was no statistically significant difference between the drugs with respect to the estradiol levels, and Divina produced higher MPA concentrations than Klimaxil and the combination of Trisequence and Provera, although the mean AUC was not twice as high, as might have been expected. Expand
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