Pharmacokinetics and Pharmacodynamics of Rapacuronium in Patients with Cirrhosis

  title={Pharmacokinetics and Pharmacodynamics of Rapacuronium in Patients with Cirrhosis},
  author={Philippe Duvaldestin and Velislav Slavov and Yves Rebufat},
Background: Delayed elimination kinetics of steroidal neuromuscular blocking agents have been observed in patients with cirrhosis. Like other steroidal muscle relaxants, rapacuronium may, in part, be eliminated by the liver. To determine the influence of liver disease on its neuromuscular blocking effect, we studied the pharmacokinetics and pharmacodynamics of rapacuronium in patients with cirrhosis. Methods: Sixteen patients undergoing elective surgery or endoscopy with general anesthesia… CONTINUE READING


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Publications referenced by this paper.

Onset of rapacuronium : A comparison with rocuronium ( abstract )

  • T Witkowski, R Bartkowski, S Huffndgk, J Lessin, A Marr
  • 1998

Dose - ranging study in younger adult and elderly patients of rapacuronium , a new , rapid - onset , short - duration muscle relaxant

  • R Kahwaji, DR Bevan, +5 authors R Matteo
  • Anesth Analg
  • 1997

The pharmacokinetics and phdrmacodynamics of rocuronium in patients with hepatic cirrhosis

  • MM VanMiert, Eastwood, AH Hoyd, Parker CJR, HunterJM
  • Br J Clin Pharmacol
  • 1997

Effect of isoflurane ans sevoflurdne on the magnitude and time course of neuromuscular block produced by vecuronium , pancnronium and atracurium

  • Vanlinthout LEH, Booij LHDJ, J VanEgmond, EN Robertson
  • Br J Anaesth
  • 1996

Pharmdcokinetics and pharmacodynamics of cisatracurium in patients with end - stage liver disease undergoing liver transplantation

  • AM DeWolf, JA Freeman, +5 authors K Cook
  • Br J Anaesth
  • 1996

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