Pharmacokinetics and Pharmacodynamics of Methylecgonidine, a Crack Cocaine Pyrolyzate

@article{Scheidweiler2003PharmacokineticsAP,
  title={Pharmacokinetics and Pharmacodynamics of Methylecgonidine, a Crack Cocaine Pyrolyzate},
  author={Karl B. Scheidweiler and Mark A. Plessinger and Jalil Shojaie and Ronald W. Wood and Tai C. Kwong},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2003},
  volume={307},
  pages={1179 - 1187}
}
Methylecgonidine is formed from cocaine base when smoked and has been identified in biological fluids of crack smokers. Ecgonidine, a metabolite of methylecgonidine formed via esterase activity, also has been identified in similar samples collected from crack smokers. Methylecgonidine and ecgonidine can be used as biomarkers to differentiate smoking from cocaine use via other routes of administration. We determined the pharmacokinetic properties of methylecgonidine and ecgonidine in sheep after… 
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