Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors

@article{Abdelkawy2016PharmacokineticsAP,
  title={Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors},
  author={Khaled Sobhy Abdelkawy and Kelsey Lack and Fawzy Elbarbry},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2016},
  volume={42},
  pages={355-370}
}
Up-regulation of arginase activity in several chronic disease conditions, including cancer and hypertension, may suggest new targets for treatment. Recently, the number of new arginase inhibitors with promising therapeutic effects for asthma, cancer, hypertension, diabetes mellitus, and erectile dysfunction has shown a remarkable increase. Arginase inhibitors may be chemical substances, such as boron-based amino acid derivatives, α-difluoromethylornithine (DMFO), and Nω-hydroxy-nor-l-arginine… CONTINUE READING
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