Pharmacokinetics and Pharmacodynamics of Lurasidone Hydrochloride, a Second-Generation Antipsychotic: A Systematic Review of the Published Literature

@article{Greenberg2016PharmacokineticsAP,
  title={Pharmacokinetics and Pharmacodynamics of Lurasidone Hydrochloride, a Second-Generation Antipsychotic: A Systematic Review of the Published Literature},
  author={William M Greenberg and Leslie Citrome},
  journal={Clinical Pharmacokinetics},
  year={2016},
  volume={56},
  pages={493-503}
}
Lurasidone hydrochloride, a benzisothiazol derivative, is a second-generation (atypical) antipsychotic agent that has received regulatory approval for the treatment of schizophrenia in the US, Canada, the EU, Switzerland, and Australia, and also for bipolar depression in the US and Canada. In addition to its principal antagonist activity at dopamine D2 and serotonin 5-HT2A receptors, lurasidone has distinctive 5-HT7 antagonistic activity, and displays partial agonism at 5-HT1A receptors, as… 

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Lurasidone is a novel second-generation antipsychotic approved for the treatment of schizophrenia and bipolar depression in adults. It displays high affinity for D2 and 5-HT2A and 5-HT7 receptors,

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TLDR
Available research findings indicate that LRSD is effective and well-tolerated for short-term treatment of schizophrenia, and for acute bipolar depression, but its risk of akathisia may exceed that of other modern antipsychotics.

Practical Guidance on the Use of Lurasidone for the Treatment of Adults with Schizophrenia

TLDR
Given the crucial importance of addressing the physical as well as mental healthcare needs of patients, lurasidone is a rational therapeutic choice for adults with schizophrenia, both in the acute setting and over the long term.

Sustained Impairment of Lurasidone Clearance After Discontinuation of Posaconazole: Impact of Obesity, and Implications for Patient Safety

TLDR
This study evaluated the time-course of recovery from the posaconazole drug interaction, and the effect of obesity on the recovery process, and recommended requiring normal-weight and obese patients to limit the dosage of lurasidone, or undergo a washout period, for two and three weeks, respectively, after discontinuation of posaconzole.

The Effect of Chronic Treatment with Lurasidone on Rat Liver Cytochrome P450 Expression and Activity in the Chronic Mild Stress Model of Depression

TLDR
It can be suggested that the metabolism of endogenous substrates and drugs, catalyzed by the isoforms CYP 2B, CYP2C11, or CYP3A, may proceed at a different rate in the two groups of animals (nonstressed and stressed) in the rat CMS model.

Identification of clinical phenotypes in schizophrenia: the role of lurasidone

TLDR
It is established that lurasidone is suggested at any age, with no gender difference, at all stages of the disease, and is among the best-tolerated antipsychotics, and its use is indicated in the presence of different comorbidities.

Lurasidone for Adolescents With Complex Mental Disorders: A Case Series

TLDR
Preliminary data supporting lurasidone’s potential use in adolescents of complex clinical needs (but without a clinical diagnosis of bipolar disorder) within real-life clinical settings is provided.

Asenapine, iloperidone and lurasidone exposures in young children reported to U.S. poison centers

TLDR
It is suggested that in children under 6 years of age, lurasidone exposures were least serious and iloperidones exposures were most serious based on clinical effects, management sites and coded outcomes.

Lurasidone in the Treatment of Bipolar Depression: Systematic Review of Systematic Reviews

TLDR
This overview stipulates the effectiveness of lurasidone in the acute treatment of Type I bipolar depression overall, and recommendations for future research should include further controlled trials of extended duration.

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