Pharmacokinetics and Pharmacodynamics of LGD-3303 [9-Chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an Orally Available Nonsteroidal-Selective Androgen Receptor Modulator

@article{Vajda2009PharmacokineticsAP,
  title={Pharmacokinetics and Pharmacodynamics of LGD-3303 [9-Chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an Orally Available Nonsteroidal-Selective Androgen Receptor Modulator},
  author={Eric G. Vajda and Francisco J. L{\'o}pez and Peter J. Rix and Robert Hill and Yanling Chen and Kyoung Jin Lee and Zhihong O’Brien and William Y. Chang and Martin D. Meglasson and Yong-Hee Lee},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2009},
  volume={328},
  pages={663 - 670}
}
Selective androgen receptor modulators (SARMs) are a new class of molecules in development to treat a variety of diseases. SARMs maintain the beneficial effects of androgens, including increased muscle mass and bone density, while having reduced activity on unwanted side effects. The mechanisms responsible for the tissue-selective activity of SARMs are not fully understood, and the pharmacokinetic (PK)/pharmacodynamic (PD) relationships are poorly described. Tissue-specific compound… 

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