Pharmacokinetics and Pharmacodynamics of Cannabinoids

@article{Grotenhermen2003PharmacokineticsAP,
  title={Pharmacokinetics and Pharmacodynamics of Cannabinoids},
  author={Franjo Grotenhermen},
  journal={Clinical Pharmacokinetics},
  year={2003},
  volume={42},
  pages={327-360}
}
AbstractΔ9-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects caused by the consumption of cannabis, both the marijuana-like action and the medicinal benefits of the plant. However, its acid metabolite THC-COOH, the non-psychotropic cannabidiol (CBD), several cannabinoid analogues and newly discovered modulators of the endogenous cannabinoid system are also promising candidates for clinical research and therapeutic uses. Cannabinoids exert many effects through… 
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An attempt has been made to summarize the properties of cannabis and its derivatives, and to discuss the implications of its use with emphasis on bioavailability, limit of detection, carry over period and passive inhalation, important factors for detection and diagnosis.
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