Pharmacokinetics and Pharmacodynamics of Cannabinoids

  title={Pharmacokinetics and Pharmacodynamics of Cannabinoids},
  author={F. Grotenhermen},
  journal={Clinical Pharmacokinetics},
  • F. Grotenhermen
  • Published 2003
  • Chemistry, Medicine
  • Clinical Pharmacokinetics
  • AbstractΔ9-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects caused by the consumption of cannabis, both the marijuana-like action and the medicinal benefits of the plant. However, its acid metabolite THC-COOH, the non-psychotropic cannabidiol (CBD), several cannabinoid analogues and newly discovered modulators of the endogenous cannabinoid system are also promising candidates for clinical research and therapeutic uses. Cannabinoids exert many effects through… CONTINUE READING
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    Pharmacology of cannabinoids.
    • 136
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    Pharmacokinetics of cannabinoids.
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    Human Cannabinoid Pharmacokinetics
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    • Chemistry, Medicine
    • Chemistry & biodiversity
    • 2007
    • 385
    • PDF
    Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy
    • 33
    Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol.
    • M. Huestis
    • Chemistry, Medicine
    • Handbook of experimental pharmacology
    • 2005
    • 178
    The clinical toxicology of cannabis.
    • PDF
    Cannabinoids for therapeutic use
    • 14


    Physiological and Pharmacological Interactions of Marihuana (THC) with Drugs and Anesthetics
    • 9
    • Highly Influential
    Cannabis: pharmacology and toxicology in animals and humans.
    • 516
    Cardiovascular actions of cannabinoids and their generation during shock
    • 115
    • PDF
    Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain.
    • 72
    Interactions of Marihuana and THC with Other Drugs
    • 5
    • Highly Influential
    Cannabinoid pharmacology.
    • W. Dewey
    • Medicine
    • Pharmacological reviews
    • 1986
    • 275
    • Highly Influential
    Marihuana and medicine
    • 60
    The Cannabinoids as Potential Antiepileptics
    • 111
    • PDF
    Evidence that cannabidiol does not significantly alter the pharmacokinetics of tetrahydrocannabinol in man
    • 31
    Cannabidiol interferes with the effects of delta 9 - tetrahydrocannabinol in man.
    • 253