Pharmacokinetics and Pharmacodynamics of Cannabinoids

@article{Grotenhermen2003PharmacokineticsAP,
  title={Pharmacokinetics and Pharmacodynamics of Cannabinoids},
  author={F. Grotenhermen},
  journal={Clinical Pharmacokinetics},
  year={2003},
  volume={42},
  pages={327-360}
}
  • F. Grotenhermen
  • Published 2003
  • Chemistry, Medicine
  • Clinical Pharmacokinetics
    • AbstractΔ9-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects caused by the consumption of cannabis, both the marijuana-like action and the medicinal benefits of the plant. However, its acid metabolite THC-COOH, the non-psychotropic cannabidiol (CBD), several cannabinoid analogues and newly discovered modulators of the endogenous cannabinoid system are also promising candidates for clinical research and therapeutic uses. Cannabinoids exert many effects through… CONTINUE READING
    View on Springer
    csatc.org
    830 Citations
    Highly Influential Citations
    79
    Background Citations
    358
    Methods Citations
    34
    Results Citations
    15

    Paper Mentions

    Interventional Clinical Trial
    The Kinetics of Endocannabinoids in Patients With Chemotherapy Induced Peripheral Neuropathy by Using Medical Cannabis.
    Chemotherapy-induced peripheral neuropathy (CIPN) is the most common neurological cancer treatment complication. Medical cannabis is indicated in Israel for the treatment of chronic… Expand
    ConditionsChemotherapy-induced Peripheral Neuropathy
    InterventionDrug
    HaEmek Medical Center, Israel
    June 2020 - February 2023
    Observational Patient Registry Clinical Trial
    Fetal Exposure to Cannabinoids: Exposure, Methylation and Neurodevelopmental Effects
    Cannabis is a very popular drug for both recreational and medicinal use. An estimated 20% of adults in the United States report using cannabis in the past month, and this number… Expand
    ConditionsFetal Exposure Timing Unspecified
    University of Arkansas
    February 2020 - August 2021
    Interventional Clinical Trial
    Endourage Complete Spectrum Oral Mucosal Drops (OMD) in Adults Desiring a Reduction in Ethanol Use
    This is the first clinical trial of Endourage OMD 1200 for persons desiring to reduce their alcohol consumption.  
    ConditionsAlcohol Abstinence, Alcohol Drinking, Alcohol-Related Disorders, (+1 more)
    InterventionDietary Supplement, Other
    Endourage, LLC
    January 2021 - April 2021
    News Article
    Cannabis edibles pose serious risks to our kids
    The Conversation
    19 January 2020
    News Article
    How Long Does A Marijuana High Last? It Depends On A Few Factors
    The Fresh Toast
    28 December 2019
    830 Citations
    Citation Type

    Citation Type

    The pharmacokinetics and the pharmacodynamics of cannabinoids.
    • 50
    Pharmacology of cannabinoids.
    • 136
    • PDF
    Pharmacokinetics of cannabinoids.
    • 112
    • PDF
    Human Cannabinoid Pharmacokinetics
    • M. Huestis
    • Chemistry, Medicine
    • Chemistry & biodiversity
    • 2007
    • 385
    • PDF
    Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy
    • 33
    Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol.
    • M. Huestis
    • Chemistry, Medicine
    • Handbook of experimental pharmacology
    • 2005
    • 178
    Cannabis sativa: much more beyond Δ9-tetrahydrocannabinol.
    • 6
    The clinical toxicology of cannabis.
    • PDF
    Chemistry, Metabolism, and Toxicology of Cannabis: Clinical Implications
    • 163
    • PDF
    Cannabinoids for therapeutic use
    • 14

    References

    SHOWING 1-10 OF 416 REFERENCES
    Physiological and Pharmacological Interactions of Marihuana (THC) with Drugs and Anesthetics
    • 9
    • Highly Influential
    Cannabis: pharmacology and toxicology in animals and humans.
    • 516
    Cardiovascular actions of cannabinoids and their generation during shock
    • 115
    • PDF
    Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain.
    • 72
    Interactions of Marihuana and THC with Other Drugs
    • 5
    • Highly Influential
    Cannabinoid pharmacology.
    • W. Dewey
    • Medicine
    • Pharmacological reviews
    • 1986
    • 275
    • Highly Influential
    Marihuana and medicine
    • 60
    The Cannabinoids as Potential Antiepileptics
    • 111
    • PDF
    Evidence that cannabidiol does not significantly alter the pharmacokinetics of tetrahydrocannabinol in man
    • 31
    Cannabidiol interferes with the effects of delta 9 - tetrahydrocannabinol in man.
    • 253