Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids

@article{Czock2005PharmacokineticsAP,
  title={Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids},
  author={D. Czock and F. Keller and F. Rasche and Ulla Haeussler},
  journal={Clinical Pharmacokinetics},
  year={2005},
  volume={44},
  pages={61-98}
}
Glucocorticoids have pleiotropic effects that are used to treat diverse diseases such as asthma, rheumatoid arthritis, systemic lupus erythematosus and acute kidney transplant rejection. [...] Key Method We performed simulations with a pharmacokinetic/pharmacodynamic model using T helper cell counts and endogenous Cortisol as biomarkers for the effects of methylprednisolone. These simulations suggest that the clinical efficacy of low-dose glucocorticoid regimens might be increased with twice-daily…Expand
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