Pharmacokinetics and Pharmacodynamics of Conjugated Equine Estrogens: Chemistry and Metabolism

@article{Bhavnani1998PharmacokineticsAP,
  title={Pharmacokinetics and Pharmacodynamics of Conjugated Equine Estrogens: Chemistry and Metabolism},
  author={Bhagu R. Bhavnani},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1998},
  volume={217},
  pages={16 - 6}
}
  • B. Bhavnani
  • Published 1998
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine
Abstact Conjugated equine estrogens (Premarin), are used extensively for estrogen replacement therapy and prevention of osteoporosis and cardiovascular disease in postmenopausal women. Premarin contains at least 10 estrogens that are the sulfate esters of the ring B saturated estrogens: estrone, 17β-estradiol,17α-estradiol, and the ring B unsaturated estrogens: equillin, 17β-dihydroequilin, 17α-dihydroequilin, equilenin, 17β-dihydroequilenin, 17α-dihydroequilenin, and delta-8-estrone. Bioassays… Expand
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