Pharmacokinetics and PET imaging properties of two recombinant anti-PSMA antibody fragments in comparison to their parental antibody.

@article{Wiehr2014PharmacokineticsAP,
  title={Pharmacokinetics and PET imaging properties of two recombinant anti-PSMA antibody fragments in comparison to their parental antibody.},
  author={Stefan Wiehr and Patrick Buehler and Dorothee Gierschner and Philipp Dipl.-Ing. Wolf and Anna-Maria Rolle and Christian Kesenheimer and Bernd J. Pichler and Ursula Els{\"a}sser-Beile},
  journal={The Prostate},
  year={2014},
  volume={74 7},
  pages={
          743-55
        }
}
BACKGROUND Radioimmunoimaging with disease-specific tracers can be advantageous compared to that with nonspecific tracers for the imaging of glucose metabolism and cell proliferation. Monoclonal antibodies (mAbs) or their fragments are excellent tools for immuno-positron emission tomography (PET). In this study, PSMA-specific mAb 3/F11 and its recombinant fragments were compared for the imaging of prostate cancer in xenografts. METHODS Recombinant anti-PSMA antibody fragments D7-Fc and D7-CH3… CONTINUE READING