Pharmacokinetics and Oral Bioavailability of Scopolamine in Normal Subjects

  title={Pharmacokinetics and Oral Bioavailability of Scopolamine in Normal Subjects},
  author={Lakshmi Putcha and Nitza M. Cintr{\'o}n and James K Tsui and James M. Vanderploeg and William G. Kramer},
  journal={Pharmaceutical Research},
The pharmacokinetics and bioavailability of scopolamine were evaluated in six healthy male subjects receiving 0.4 mg of the drug by either oral or intravenous administration. Plasma and urine samples were analyzed using a radioreceptor binding assay. After iv administration, scopolamine concentrations in the plasma declined in a biexponential fashion, with a rapid distribution phase and a comparatively slow elimination phase. Mean and SE values for volume of distribution, systemic clearance… CONTINUE READING

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