Pharmacokinetics and Metabolism of Bisoprolol-14C in Three Animal Species and in Humans

@article{Bhring1986PharmacokineticsAM,
  title={Pharmacokinetics and Metabolism of Bisoprolol-14C in Three Animal Species and in Humans},
  author={K. U. B{\"u}hring and Holger Sailer and H. P. Faro and G. Leopold and Joachim Pabst and A. Garbe},
  journal={Journal of Cardiovascular Pharmacology},
  year={1986},
  volume={8},
  pages={S21–S28}
}
&NA; The pharmacokinetic properties of bisoprolol‐14C were studied in Wistar rats, beagle dogs, and Cynomolgus monkeys. Bisoprolol is well absorbed in these species; independent of the route of administration (i.v. or p.o.), 70‐90% of the 14C‐dose was recovered in urine. Faecal excretion was ˜20% in rats and <10% in dogs and monkeys. Rats excreted ˜ 10% of the dose in bile after i.v. as well as after oral administration. The plasma half‐life of the unchanged drug was ˜ 1 h in rats, 3 h in… Expand
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