• Corpus ID: 36756573

Pharmacokinetics and Mechanisms of Action of Carbon Monoxide

  title={Pharmacokinetics and Mechanisms of Action of Carbon Monoxide},
  • Published 2006
  • Chemistry
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Highly sensitive quantification of carbon monoxide (CO) in vivo reveals a protective role of circulating hemoglobin in CO intoxication
The properties and usage of hemoCD1, a synthetic supramolecular compound, are reported as an accessible reagent for a simple colorimetric assay to quantify CO in biological samples, showing that it acts as effective adjuvant to O2 ventilation to eliminate residual CO accumulated in organs, including the brain.


Absorption and elimination of carbon monoxide by inactive young men.
Several model equations were tested against the absorption and excretion data; one theoretical equation accurately predicted COHb levels resulting from continuous and discontinuous exposures to unvarying concentrations and from continuous exposure to a steadily rising concentration.
Carboxyhemoglobin Levels in Humans: Effects of Altitude
The effects of altitude on endogenous blood carboxyhemoglobin (COHb) concentrations and on COHb concentrations produced by breathing carbon monoxide (CO) were determined and the overall increase for both groups was approximately 20%.
Effect of regional circulation patterns on observed HbCO levels.
An expanded model was derived from the Coburn-Forster-Kane equation, which reflects the above hypothesis, and most of the parameter values for the expanded model were measured on individual subjects.
The effects of cigarette smoking on total body burden and excretion rates of carbon monoxide.
  • S. Landaw
  • Medicine
    Journal of occupational medicine. : official publication of the Industrial Medical Association
  • 1973
Prediction of carboxyhemoglobin formation due to transient exposure to carbon monoxide.
Exposure of such organs as brain or heart to HbCO may be substantially higher than expected during transient high-level CO exposure, and venous blood was overestimated during CO uptake because of a delayed appearance of Hb CO.
The content of carbon monoxide in the tissues of rats intoxicated with carbon monoxide in various conditions of acute exposure
It was shown that acute CO intoxication induced by long duration exposures did not involve CO accumulation in the tissues and the time course of CO elimination was the same for blood and brain, irrespective of CO exposure conditions.
Considerations of the physiological variables that determine the blood carboxyhemoglobin concentration in man.
The CO concentrations in air samples taken from smoke-filled conference rooms, a small nonventilated room that was purposely filled with smoke by burning cigarettes, and a rural area well away from automobile combustion were measured.
Heme catabolism during short-term treatment with phenobarbital, diazepam and oxazepam.
It is concluded that although phenobarbital is known to increase the hepatic heme turnover, this effect is not measurable in terms of total he me turnover, no more than 20% of which comes from the liver.
Diurnal variation in endogenous production of carbon monoxide. Effect of caloric restriction.
It cannot be excluded that starvation affects erythropoiesis and/or red cell catabolism, thereby causing an increase in VCO and SB, and it is concluded that changes are secondary to a increase in total hemeCatabolism.