Pharmacokinetics and Clinical Use of Parenteral Phenytoin, Phenobarbital, and Paraldehyde

@article{Ramsay1989PharmacokineticsAC,
  title={Pharmacokinetics and Clinical Use of Parenteral Phenytoin, Phenobarbital, and Paraldehyde},
  author={Richard E. Ramsay},
  journal={Epilepsia},
  year={1989},
  volume={30}
}
  • R. Ramsay
  • Published 1 June 1989
  • Medicine
  • Epilepsia
Summary: Intravenous phenytoin, phenobarbital, and paraldehyde are effective and safe for the treatment of acute seizures such as status epilepticus. All of these drugs should be infused in a diluted solution and at a slow rate to minimize the occurrence of adverse effects. 
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In this study, intramuscular fosphenytoin was demonstrated to be a safe and well tolerated, and in many instances, a preferable alternative to other means of phenytoin loading.
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This document summarizes the proceedings of an expert panel consensus process addressing the nonemergency use of parenteral phenytoin products for management of seizures in pediatric and adult
Effects of paraldehyde on the convulsions induced by administration of soman in rats
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Refractory status epilepticus (RSE)-that is, seizures resistant to at least two antiepileptic drugs (AEDs)-is generally managed with barbiturates, propofol, or midazolam, despite a low level of evidence, and the need for alternative pharmacologic and nonpharmacologic strategies emerges.
Practical management of therapeutic diphenylhydantoin concentrations in children.
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Therapeutic DPH concentration profiles can be managed satisfactorily in children in individual-specific DPH pharmacokinetic parameters derived and skillfully applied.
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TLDR
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TLDR
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TLDR
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TLDR
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SOME EXPERIMENTAL AND CLINICAL OBSERVATIONS ON THE ANTICONVULSIVE ACTION OF PARALDEHYDE*
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