Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging

@inproceedings{Kamath2012PharmacokineticsAB,
  title={Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging},
  author={Amrita V. Kamath and Simon D. P. Williams and Sherry Bullens and Kyra Juliana Cowan and Yvonne Stenberg and Simon R. Cherry and Stephen V Rendig and David L. Kukis and Chris D. Griesemer and Lisa A. Damico-Beyer and Stuart Bunting},
  booktitle={PloS one},
  year={2012}
}
PURPOSE Oxidized low-density lipoprotein (LDL) plays an essential role in the pathogenesis of atherosclerosis. The purpose of this study was to characterize the pharmacokinetics (PK) of a human recombinant IgG1 antibody to oxidized LDL (anti-oxLDL) in cynomolgus monkey. The tissue biodistribution of anti-oxLDL was also investigated using positron emission tomography (PET) imaging. METHODS Anti-oxLDL was conjugated with the N-hydroxysuccinimide ester of DOTA (1,4,7,10-tetraazacyclododecane 1,4… CONTINUE READING
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