Pharmacokinetics and Bioavailability of Hydromorphone Following Intravenous and Oral Administration to Human Subjects

@article{Vallner1981PharmacokineticsAB,
  title={Pharmacokinetics and Bioavailability of Hydromorphone Following Intravenous and Oral Administration to Human Subjects},
  author={J. J. Vallner and James T. Stewart and Jeffrey A. Kotzan and Edward B. Kirsten and I. L. Honigberg},
  journal={The Journal of Clinical Pharmacology},
  year={1981},
  volume={21}
}
Abstract: In a relatively small pilot study, the half‐life of elimination of hydromorphone in six subjects was 2.64 ± 0.88 hours and the drug had a high volume of distribution, 1.22 1./kg. In addition, the drug was rapidly but incompletely absorbed after oral administration. An equation to predict the plasma concentration of hydromorphone on oral administration was developed from the data of these six subjects. 
Pharmacokinetics of hydromorphone after intravenous, peroral and rectal administration to human subjects
TLDR
The pharmacokinetic properties of hydromorphone in healthy young male subjects were studied after i.v., peroral, and rectal administration and the absolute bioavailability after peroral administration was 50.7 ± 29.8 per cent.
Absolute Bioavailability of Hydromorphone After Peroral and Rectal Administration in Humans: Saliva/Plasma Ratio and Clinical Effects
TLDR
The saliva sampling for the hydromorphone concentration was found to be a useful noninvasive technique for the estimation of the elimination half‐life of hydromOrphone.
Input Characteristics and Bioavailability after Administration of Immediate and a New Extended-release Formulation of Hydromorphone in Healthy Volunteers
TLDR
The extended release of hydromorphone will produce less fluctuation of plasma concentrations compared with IR formulations, which should provide for more constant pain control, and the increased bioavailability from the OROS® formulation may be related to decreased metabolism by a first-pass effect or enterohepatic recycling of hydomorphone.
Multiple‐Dose Evaluation of Intravenous Hydromorphone Pharmacokinetics in Normal Human Subjects
TLDR
The results indicate that hydromorphone pharmacokinetic parameters are linear across a fourfold range of doses that are usually employed clinically and that previously reported pharmacokinetics values for hydromoassay deserve reconsideration.
Pharmacokinetics and Bioavailability of Single-Dose Intranasal Hydromorphone Hydrochloride in Healthy Volunteers
TLDR
IN hydromorphone hydrochloride met the minimum requirements for safety and demonstrated rapid nasal drug absorption and clinically relevant bioavailability in a single dose and support further development of this novel hydromorephone hydro chloride nasal spray.
Rifampin Reduces the Plasma Concentrations of Oral and Intravenous Hydromorphone in Healthy Volunteers
TLDR
The enhancement of hydromorphone elimination should be considered when managing pain of patients who are treated with strong enzyme inducers, likely involving induction of uridine 5′-diphospho- glucuronosyltransferase enzymes by rifampin.
The concentration of digoxin after intravenous and oral administration studied by a two-compartment model
TLDR
This paper is designed to compare the distribution of digoxin administered through an Intravenous (i.v.) and Oral (p.o.) system in central and peripheral compartments.
Pharmacokinetic investigation of dose proportionality with a 24-hour controlled-release formulation of hydromorphone
TLDR
The pharmacokinetics of OROS® hydromorphone are linear and dose proportional for the 8, 16, 32, and 64 mg doses.
Single‐dose evaluation of safety, tolerability and pharmacokinetics of newly formulated hydromorphone immediate‐release and hydrophilic matrix extended‐release tablets in healthy Japanese subjects without co‐administration of an opioid antagonist
TLDR
A single oral administration of the hydromorphone tablets would be well‐tolerated in healthy Japanese subjects despite a lack of co‐administration of an opioid antagonist and the newly developed ER hydrom orphone tablets may have the appropriate PK characteristics for once‐daily dosing.
A Multiple-Dose Phase I Study of Intranasal Hydromorphone Hydrochloride in Healthy Volunteers
TLDR
Intranasal hydromorphone hydrochloride nasal spray was well tolerated and demonstrated rapid nasal drug absorption and predictable accumulation in an open-label, single- and multiple-dose study.
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