Pharmacokinetics: optimising safe and effective prescribing

  title={Pharmacokinetics: optimising safe and effective prescribing},
  author={Susan Mayor},
  • S. Mayor
  • Published 1 March 2017
  • Medicine
  • Prescriber
This article goes back to basics with an update on pharmacokinetics, examining how underlying processes in the body influence the clinical effects and risk of side‐effects of drugs that GPs commonly prescribe. 
1 Citations
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  • Jodie Coulson
  • Medicine
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  • 2020
The pharmacokinetic factors that affect medicine absorption are discussed and the four principles of medicines optimisation are examined and how nurses can use these to ensure the safe and effective use of medicines.


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Although genotype tests can determine if a patient has a specific enzyme polymorphism, it has not been determined if routine use of these tests will improve outcomes and knowledge of the most important drugs metabolized by cytochrome P450 enzymes, as well as the most potent inhibiting and inducing drugs, can help minimize the possibility of adverse drug reactions and interactions.
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The burden ofADRs on the NHS is high, accounting for considerable morbidity, mortality, and extra costs, and measures need to be put into place to reduce the burden of ADRs and thereby further improve the benefit:harm ratio of the drugs.