Pharmacokinetics/pharmacodynamics and the stages of drug development: Role of modeling and simulation

@article{Chien2005PharmacokineticspharmacodynamicsAT,
  title={Pharmacokinetics/pharmacodynamics and the stages of drug development: Role of modeling and simulation},
  author={J. Y. L. Chien and Stuart Friedrich and Michael Heathman and Dinesh P. de Alwis and Vikram Sinha},
  journal={The AAPS Journal},
  year={2005},
  volume={7},
  pages={E544-E559}
}
Pharmacokinetic (PK) and pharmacodynamic (PD) modeling and simulation (M&S) are well-recognized powerful tools that enable effective implementation of the learn-and-confirm paradigm in drug development. The impact of PK/PD M&S on decision making and drug development risk management is dependent on the question being asked and on the availability and quality of data accessible at a particular stage of drug development. For instance, M&S methodologies can be used to capture uncertainty and use… CONTINUE READING
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