Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception.

@article{Sharma2017PharmacokineticsPA,
  title={Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception.},
  author={Anjna K. Sharma and Asmita Magotra and Ashish Kumar Dogra and Santosh Kumar Rath and Sheikh Rayees and Priya Wazir and Sadhana Sharma and Payare lal Sangwan and Surjeet Singh and Gurdarshan Singh and Utpal Nandi},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2017},
  volume={91},
  pages={
          216-225
        }
}
In spite of unprecedented advances in modern systems of medicine, there is necessity for exploration of traditional plant based secondary metabolites or their semisynthetic derivatives which may results in better therapeutic activity, low toxicity and favourable pharmacokinetics. In this context, computational model based predictions aid medicinal chemists… CONTINUE READING