Pharmacokinetics, pharmacodynamics and glucose counterregulation following subcutaneous injection of the monomeric insulin analogue [Lys(B28),Pro(B29)] in IDDM

@article{Torlone1994PharmacokineticsPA,
  title={Pharmacokinetics, pharmacodynamics and glucose counterregulation following subcutaneous injection of the monomeric insulin analogue [Lys(B28),Pro(B29)] in IDDM},
  author={Elisabetta Torlone and Carmine Fanelli and A. M. Rambotti and Georgia Kassi and F T Modarelli and Antonacci Vincenzo and L. Epifano and Marco Ciofetta and Simone Pampanelli and Paolo Brunetti and Geramia B. Bolli},
  journal={Diabetologia},
  year={1994},
  volume={37},
  pages={713-720}
}
The aim of these studies was to compare the pharmacokinetics, pharmacodynamics, counterregulatory hormone and symptom responses, as well as cognitive function during hypoglycaemia induced by s. c. injection of 0.15 IU/kg of regular human insulin (HI) and the monomeric insulin analogue [Lys(B28),Pro (B29)] (MI) in insulin-dependent-diabetic (IDDM) subjects. In these studies glucose was infused whenever needed to prevent decreases in plasma glucose below 3 mmol/l. After MI, plasma insulin… CONTINUE READING