Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus.

@article{Kolterman2005PharmacokineticsPA,
  title={Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus.},
  author={Orville G. Kolterman and Dennis D. Kim and Larry Z. Shen and James A Ruggles and Loretta L. Nielsen and Mark S Fineman and Alain D. Baron},
  journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists},
  year={2005},
  volume={62 2},
  pages={173-81}
}
PURPOSE The pharmacology and tolerability of exenatide in patients with type 2 diabetes mellitus were studied. METHODS Two randomized, single-blind, placebo-controlled studies were conducted. Treatment with oral antidiabetic agents was stopped 14 days before study initiation. In the first study (study A), eight subjects received placebo, 0.1-, 0.2-, 0.3-, and either 0.4-microg/kg exenatide or placebo five minutes before a meal combined with liquid acetaminophen (to assess the rate of gastric… CONTINUE READING
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