Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates.

@article{Yang2004PharmacokineticsMD,
  title={Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates.},
  author={Zhijian Yang and Junhua Wang and Takayuki Yoshioka and Baoqiu Li and Quan Lu and Shukuan Li and Xinghua Sun and Yuying Tan and Shigeo Yagi and Eugene P. Frenkel and Robert M Hoffman},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 6},
  pages={2131-8}
}
Pharmacokinetics, methionine depletion, antigenicity, and toxicity of recombinant methioninase (rMETase), which has shown efficacy in achieving cell kill in a broad range of human tumor models, were examined in macaque monkeys. Dose-ranging studies at 1000, 2000, and 4000 units/kg i.v. identified the 4000 units/kg dose as able to reduce plasma methionine to an undetectable level (less than 0.5 microM) by 30 min, and the level so remained for 8 h. Pharmacokinetic analysis showed that rMETase was… CONTINUE READING
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