Pharmacokinetics, metabolism, and excretion of nefopam, a dual reuptake inhibitor in healthy male volunteers

@article{Sanga2016PharmacokineticsMA,
  title={Pharmacokinetics, metabolism, and excretion of nefopam, a dual reuptake inhibitor in healthy male volunteers},
  author={Madhu Sanga and John Banach and A. Ledvina and N. Modi and Aravind Mittur},
  journal={Xenobiotica},
  year={2016},
  volume={46},
  pages={1001 - 1016}
}
  • Madhu Sanga, John Banach, +2 authors Aravind Mittur
  • Published 2016
  • Chemistry, Medicine
  • Xenobiotica
  • Abstract 1. The disposition of nefopam, a serotonin–norepinephrine reuptake inhibitor, was characterized in eight healthy male volunteers following a single oral dose of 75 mg [14C]-nefopam (100 μCi). Blood, urine, and feces were sampled for 168 h post-dose. 2. Mean (± SD) maximum blood and plasma radioactivity concentrations were 359 ± 34.2 and 638 ± 64.7 ngEq free base/g, respectively, at 2 h post-dose. Recovery of radioactive dose was complete (mean 92.6%); a mean of 79.3% and 13.4% of the… CONTINUE READING
    5 Citations

    Topics from this paper

    References

    SHOWING 1-10 OF 21 REFERENCES
    Comparative pharmacokinetics and pharmacodynamics of intravenous and oral nefopam in healthy volunteers.
    • 42
    • Highly Influential
    Effect of Route of Administration on the Pharmacokinetic Behavior of Enantiomers of Nefopam and Desmethylnefopam
    • 13
    Nefopam Pharmacokinetics in Patients with End-Stage Renal Disease
    • 12
    Stereoselective demethylation of the enantiomers of nefopam, an experimental antidepressant and skeletal muscle relaxant.
    • 15
    Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy
    • 88
    • Highly Influential
    Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception.
    • 49
    Drug metabolite concentration-time profiles: influence of route of drug administration.
    • 30
    Nefopam and Ketamine Comparably Enhance Postoperative Analgesia
    • 97
    Involvement of central serotonergic pathways in nefopam-induced antinociception.
    • 30
    Nefopam for the prevention of postoperative pain: quantitative systematic review.
    • 94
    • PDF