Pharmacokinetics, metabolism, and excretion of nefopam, a dual reuptake inhibitor in healthy male volunteers
@article{Sanga2016PharmacokineticsMA, title={Pharmacokinetics, metabolism, and excretion of nefopam, a dual reuptake inhibitor in healthy male volunteers}, author={Madhu Sanga and John Banach and A. Ledvina and N. Modi and Aravind Mittur}, journal={Xenobiotica}, year={2016}, volume={46}, pages={1001 - 1016} }
Abstract 1. The disposition of nefopam, a serotonin–norepinephrine reuptake inhibitor, was characterized in eight healthy male volunteers following a single oral dose of 75 mg [14C]-nefopam (100 μCi). Blood, urine, and feces were sampled for 168 h post-dose. 2. Mean (± SD) maximum blood and plasma radioactivity concentrations were 359 ± 34.2 and 638 ± 64.7 ngEq free base/g, respectively, at 2 h post-dose. Recovery of radioactive dose was complete (mean 92.6%); a mean of 79.3% and 13.4% of the… CONTINUE READING
Topics from this paper
Paper Mentions
5 Citations
An open-label, single-dose, phase 1 study of the absorption, metabolism and excretion of quizartinib, a highly selective and potent FLT3 tyrosine kinase inhibitor, in healthy male subjects, for the treatment of acute myeloid leukemia
- Biology, Medicine
- Xenobiotica; the fate of foreign compounds in biological systems
- 2017
- 20
A Simultaneous Mixed-Effects Pharmacokinetic Model for Nefopam, N-desmethylnefopam, and Nefopam N-Oxide in Human Plasma and Urine
- Medicine, Chemistry
- European Journal of Drug Metabolism and Pharmacokinetics
- 2017
- 1
Comparison Between Preoperative and Intraoperative Administration of Nefopam for Acute and Chronic Postoperative Pain in Colon Cancer Patients: A Prospective, Randomized, Double-Blind Study
- Medicine
- World Journal of Surgery
- 2019
MetaQSAR: An Integrated Database Engine to Manage and Analyze Metabolic Data.
- Chemistry, Medicine
- Journal of medicinal chemistry
- 2018
- 5
References
SHOWING 1-10 OF 21 REFERENCES
Comparative pharmacokinetics and pharmacodynamics of intravenous and oral nefopam in healthy volunteers.
- Medicine
- Pharmacology & toxicology
- 2003
- 42
- Highly Influential
Effect of Route of Administration on the Pharmacokinetic Behavior of Enantiomers of Nefopam and Desmethylnefopam
- Chemistry, Medicine
- Therapeutic drug monitoring
- 2003
- 13
Nefopam Pharmacokinetics in Patients with End-Stage Renal Disease
- Medicine
- Anesthesia and analgesia
- 2010
- 12
Stereoselective demethylation of the enantiomers of nefopam, an experimental antidepressant and skeletal muscle relaxant.
- Chemistry, Medicine
- Xenobiotica; the fate of foreign compounds in biological systems
- 1974
- 15
Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy
- Medicine
- Drugs
- 2012
- 88
- Highly Influential
Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception.
- Medicine, Biology
- Pharmacological research
- 2006
- 49
Drug metabolite concentration-time profiles: influence of route of drug administration.
- Chemistry, Medicine
- British journal of clinical pharmacology
- 1984
- 30
Nefopam and Ketamine Comparably Enhance Postoperative Analgesia
- Medicine
- Anesthesia and analgesia
- 2005
- 97
Involvement of central serotonergic pathways in nefopam-induced antinociception.
- Medicine
- European journal of pharmacology
- 1987
- 30
Nefopam for the prevention of postoperative pain: quantitative systematic review.
- Medicine
- British journal of anaesthesia
- 2008
- 94
- PDF