Pharmacokinetics, metabolism, and disposition of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rats and monkeys.

@article{Uchiyama2011PharmacokineticsMA,
  title={Pharmacokinetics, metabolism, and disposition of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rats and monkeys.},
  author={Minoru Uchiyama and Hironobu Iwabuchi and Fujiko Tsuruta and Kuniomi Abe and Makoto Takahashi and Hiroko Koda and Minoru Oguchi and Osamu Okazaki and Takashi Izumi},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2011},
  volume={39 4},
  pages={
          653-66
        }
}
The pharmacokinetics, metabolism, and excretion of rivoglitazone [(RS)-5-{4-[(6-methoxy-1-methyl-1H-benzimidazol-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione monohydrochloride], a novel thiazolidinedione (TZD) peroxisome proliferator-activated receptor γ selective agonist, were evaluated in male F344/DuCrlCrlj rats and cynomolgus monkeys. The total body clearance and volume of distribution of rivoglitazone were low in both animals (0.329-0.333 ml per min/kg and 0.125-0.131 l/kg for rats and… CONTINUE READING

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