Pharmacokinetics, excretion, and mass balance of liposomal amphotericin B (AmBisome) and amphotericin B deoxycholate in humans.

@article{Bekersky2002PharmacokineticsEA,
  title={Pharmacokinetics, excretion, and mass balance of liposomal amphotericin B (AmBisome) and amphotericin B deoxycholate in humans.},
  author={Ihor Bekersky and Robert Michael George Fielding and Dawna E Dressler and Jean Wenqing. Lee and Donald N. Buell and Thomas John Walsh},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 3},
  pages={
          828-33
        }
}
The pharmacokinetics, excretion, and mass balance of liposomal amphotericin B (AmBisome) (liposomal AMB) and the conventional formulation, AMB deoxycholate (AMB-DOC), were compared in a phase IV, open-label, parallel study in healthy volunteers. After a single 2-h infusion of 2 mg of liposomal AMB/kg of body weight or 0.6 mg of AMB-DOC/kg, plasma, urine, and feces were collected for 168 h. The concentrations of AMB were determined by liquid chromatography tandem mass spectrometry (plasma, urine… CONTINUE READING
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