Pharmacokinetics, dose proportionality, and tolerability of gadobutrol after single intravenous injection in healthy volunteers.

@article{Staks1994PharmacokineticsDP,
  title={Pharmacokinetics, dose proportionality, and tolerability of gadobutrol after single intravenous injection in healthy volunteers.},
  author={Thomas Staks and Gabriele Schuhmann-Giampieri and Thomas Frenzel and Hanns Joachim Weinmann and Linda Lange and Johannes Platzek},
  journal={Investigative radiology},
  year={1994},
  volume={29 7},
  pages={709-15}
}
RATIONALE AND OBJECTIVES Gadobutrol is a new gadolinium-based hydrophilic and neutral macrocyclic contrast medium for magnetic resonance imaging. In this article, the authors report on the first application of gadobutrol in humans, up to a dose of 0.5 mmol/kg. METHODS Gadobutrol was investigated after single intravenous administration in two phase-1 studies testing low (0.5 mol/L) and high concentrations (1 mol/L) in healthy, male volunteers using a double-blind, randomized, placebo… CONTINUE READING
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