Pharmacokinetics, distribution and excretion of YM155 monobromide, a novel small-molecule survivin suppressant, in male and pregnant or lactating female rats.

Abstract

YM155 monobromide is a novel small-molecule survivin suppressant. The pharmacokinetics, distribution and excretion of YM155/[14C]YM155 were investigated using males and pregnant or lactating female rats after a single intravenous bolus administration. For the 0.1, 0.3 and 1 mg/kg YM155 doses given to male rats, increases in area under the plasma… (More)
DOI: 10.1002/bdd.1781

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@article{Minematsu2012PharmacokineticsDA, title={Pharmacokinetics, distribution and excretion of YM155 monobromide, a novel small-molecule survivin suppressant, in male and pregnant or lactating female rats.}, author={Tsuyoshi Minematsu and Takuya Sonoda and Tadashi Hashimoto and Megumi Iwai and Todd Oppeneer and Laurie Felder and Nobuaki Shirai and Aiji Miyashita and Takashi Usui}, journal={Biopharmaceutics & drug disposition}, year={2012}, volume={33 3}, pages={160-9} }