Pharmacokinetics, brain distribution and pharmaco-electrocorticographic profile of zolpidem, a new hypnotic, in the rat.

@article{GarrigouGadenne1989PharmacokineticsBD,
  title={Pharmacokinetics, brain distribution and pharmaco-electrocorticographic profile of zolpidem, a new hypnotic, in the rat.},
  author={Danielle Garrigou-Gadenne and John E. T. Burke and Alain Durand and Henri Depoortere and Jean Paul Th{\'e}not and Paolo Lucio Morselli},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={248 3},
  pages={1283-8}
}
Zolpidem [N,N-6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3- acetamide] administered as the hemitartrate salt has proven to be an effective hypnotic agent in animals and humans. This study describes the pharmacokinetic behavior of zolpidem in plasma and brain of rat after i.v. and p.o. administration of 2.63 mg.kg-1 of [14C]zolpidem (dose expressed as the base). Autoradiography was used to examine the regional distribution of the compound and the metabolic profile of zolpidem in the… CONTINUE READING

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