Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans.

@article{Bathala2012PharmacokineticsBA,
  title={Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans.},
  author={Mohinder Singh Bathala and Hiroshi Masumoto and Toshihiro Oguma and Ling He and Chris Lowrie and Jeanne Mendell},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2012},
  volume={40 12},
  pages={2250-5}
}
This study determined the mass balance and pharmacokinetics of edoxaban in humans after oral administration of [¹⁴C]edoxaban. After oral administration of 60 mg (as active moiety) of [¹⁴C]edoxaban to six healthy male subjects, serial blood/plasma and urinary and fecal samples were collected for up to 168 h postdose. All samples were analyzed for total radioactivity by liquid scintillation counting and for concentrations of edoxaban and four metabolites in plasma, urine, and fecal samples by… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 68 extracted citations

Edoxaban: a focused review of its clinical pharmacology.

European heart journal • 2014
View 4 Excerpts
Highly Influenced

Target-specific oral anticoagulants and the hospitalist.

Hospital practice • 2015
View 7 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 11 references

metabolism of edoxaban and the enzymes involved in the oxidative metabolism of edoxaban

N W4308. Matsushima, F Lee, T Sato, D Weiss, J Mendell
AAPS J 12(Suppl • 2011

Biotransformation of edoxaban

M Bathala, H Masumoto, T Oguma, J Mendell
2010

direct factor Xa inhibition with edoxaban for thromboprophylaxis after elective total hip replacement. A randomised double-blind dose-response study

CT Ruff, RP Giugliano, +9 authors E Braunwald
Thromb Haemost • 2010
View 2 Excerpts

Guidance for industry—safety testing of drug metabolites. US Food and Drug Administration, Rockville, MD

AT Cohen, G Agnelli, +5 authors JA Heit
Center for Drug Evaluation and Research • 2008

VTE Impact Assessment Group in Europe (VITAE

JL Hutchinson, AK Kakkar, +3 authors M Spannagl
Thromb Haemost • 2007

Similar Papers

Loading similar papers…