Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion.

@article{Hao2006PharmacokineticsAA,
  title={Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion.},
  author={Haiping Hao and Guang-ji Wang and Nan Cui and Jing Li and Lin Xie and Zuoqi Ding},
  journal={Planta medica},
  year={2006},
  volume={72 14},
  pages={1311-7}
}
This study was designed to elucidate the pharmacokinetics, absorption, tissue distribution and plasma protein binding properties of tanshinone IIA, a highly lipophilic compound isolated from Salvia miltiorrhiza. Tanshinone IIA was isolated using a previously well developed LC-MS/MS method. Its pharmacokinetic characteristics, absolute bioavailability, tissue distribution and plasma protein binding properties were determined. The membrane permeability was evaluated using Caco-2 cells in… CONTINUE READING

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