Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man

@article{Vree1990PharmacokineticsNA,
  title={Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man},
  author={Dr. T. B. Vree and E. W. J. Beneken Kolmer and M. Martea and Ruud J. L. H. Bosch and Dr. Y. A. Hekster and Minoru Shimoda},
  journal={Pharmaceutisch Weekblad},
  year={1990},
  volume={12},
  pages={51-59}
}
Sulfadimethoxine is metabolized byO-dealkylation, N4-acetylation and N1-glucuronidation. In man, only N1-glucuronidation and N4-acetylation takes place, leading to the final double conjugate N4-acetylsulfadimethoxine-N1-glucuronide. The N1-glucuronides are directly measured by high pressure liquid chromatography. When N4-acetylsulfadimethoxine is administered as parent drug, 30% of the dose is N1-glucuronidated and excreted. Fast acetylators show a shorter half-life for sulfadimethoxine than… CONTINUE READING
1 Citations
36 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 36 references

High performance liquid chromatography of sulfadimethoxine and its Nl-glucuronide, N4-acetyl-, and N4acetyl-Nl-glucuronide metabolites in plasma and urine of man

  • TB Vree, EWJ Beneken Kolmer, M Martea, R. Bosch
  • J Chromatogr
  • 1990

ODemethylation and N4-acetylation of sulfadimethoxine by the turtle Pseudemys scripta elegans

  • TB Vree, JB Vree, N Beneken Kolmer
  • Vet Quart 1989;11:138-43
  • 1989

The role of plasma protein binding on the metabolism and renal excretion of sulfadimethoxine and its metabolite N4-acetylsulfadimethoxine in pigs

  • M Shimoda, TB Vree, EWJ Beneken Kolmer, ThHM. Arts
  • BIOTICA
  • 1988

Similar Papers

Loading similar papers…