Pharmacokinetics, Metabolism, and Excretion of Irinotecan (cpt-11) following I.v. Infusion of [c]cpt-11 in Cancer Patients


This study determined the disposition of irinotecan hydrochloride trihydrate (CPT-11) after i.v. infusion of 125 mg/m (100 mCi) [C]CPT-11 in eight patients with solid tumors. Mean 6 S.D. recovery of radioactivity in urine and feces was 95.8 6 2.7% (range 92.2–100.3%, n 5 7) of dose. Radioactivity in blood, plasma, urine, and feces was determined for at… (More)


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