Pharmacokinetics, Bioavailability, and Safety of Montelukast Sodium (MK-0476) in Healthy Males and Females

@article{Cheng1996PharmacokineticsBA,
  title={Pharmacokinetics, Bioavailability, and Safety of Montelukast Sodium (MK-0476) in Healthy Males and Females},
  author={Haiyung Cheng and Jonathan A. Leff and Raju D. Amin and Barry J. Gertz and Marina de Smet and Nancy Noonan and John Douglas Rogers and William Malbecq and D. B. Meisner and Gary F. Somers},
  journal={Pharmaceutical Research},
  year={1996},
  volume={13},
  pages={445-448}
}
Purpose. The safety, tolerability, and pharmacokinetics of intravenous (i.v.) montelukast sodium (Singulair™, MK-0476), and the oral bioavailability of montelukast sodium in healthy males and healthy females were studied. Methods. This was a two-part study. Part I was a four-period study in males of rising i.v. doses of montelukast sodium (3, 9, and 18 mg) administered as 15-minute constant-rate i.v. infusions (Periods 1–3), followed by a 10-mg oral tablet dose of montelukast sodium (Period 4… CONTINUE READING
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