Pharmacokinetic study of rhizoma Curcumae oil and rhizoma Curcumae oil-β-cyclodextrin inclusion complex in pigs after oral administration.

@article{YongXue2012PharmacokineticSO,
  title={Pharmacokinetic study of rhizoma Curcumae oil and rhizoma Curcumae oil-β-cyclodextrin inclusion complex in pigs after oral administration.},
  author={S. Yong-Xue and Lai Yongjin and Zeng Dongping and Wang Gang and Liu Zhichang and Z. Haiyan},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2012},
  volume={35 1},
  pages={
          47-51
        }
}
Pharmacokinetics of rhizoma Curcumae oil-pure drug (RCO-PD) and its β-cyclodextrin inclusion complex (RCO-βCD) were studied in a randomized two-way crossover design following a single oral administration of the two formulations. Germacrone concentrations in plasma were determined by high-performance liquid chromatography with UV detector. The concentrations vs. time data were analyzed by a noncompartmental pharmacokinetic method. The result showed that germacrone in both groups was rapidly… CONTINUE READING