Corpus ID: 68209941

Pharmacokinetic study of pseudohainanensine with deuteriumlabeled analogue as internal standard

@article{Qm1992PharmacokineticSO,
  title={Pharmacokinetic study of pseudohainanensine with deuteriumlabeled analogue as internal standard},
  author={Gu Qm},
  journal={Chinese journal of oncology},
  year={1992},
  volume={14},
  pages={51}
}
  • Gu Qm
  • Published 1992
  • Medicine
  • Chinese journal of oncology
: Pseudohainanensine (HH08) is a synthetic compound which is active against L-1210. In order to study the pharmacokinetic characteristics of this compound in rats, 3', 4'-dideuteropseudohainanensine (DH08) was synthesized and used as internal standard in GC-MS determination for quantitative analysis of alkaloid HH08 in the blood of rats that had been given HH08 at a dosage of 10 mg/kg intravenously. Experiments demonstrated that the detection limit of HH08 was 3 micrograms/ml and the peak… Expand

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